Most people know that THC, or tetrahydrocannabinol, is the chemical compound in cannabis responsible for a euphoric high. But what more is there to know about cannabis’ primary psychoactive component? Whether the question comes as a newbie to the cannabis world or an experienced consumer who would like to know a bit more about the most famous of cannabinoids, THC has likely been synonymous with cannabis in your mind for as long as you’ve known about the plant.The first step to understanding THC is to understands Cannabinoids. Cannabinoids are chemical compounds found in the cannabis plant that interact with receptors in the brain and body to create various effects. There exist dozens, and potentially more than 100, cannabinoids in the cannabis plant, but THC is most widely known among these due to its abundance and euphoric attributes.

The isolation of THC came from an Israeli chemist by the name of Raphael Mechoulam. In 1964, Mechoulam isolated and synthesized THC from Lebanese Hashish marking the beginning of cannabis research that would lead to the discovery of many other cannabinoids, cannabinoid receptors throughout the body, and “endocannabinoids” – the THC-like compounds our body naturally produces to maintain stability and healthy

Cannabinoids 101: What Makes Cannabis Medicine?

Why does cannabis produce cannabinoids? Cannabinoids are known as secondary metabolites, which means they are chemicals the plant produces that have no primary role on the plant’s development. However, most people think that it is that secondary metabolites act as an immune system for the plant, fending off predators, parasites, and pests.

Because humans (and many other animals) have receptor systems that THC binds to, we can also reap the benefits of cannabinoids for both health and enjoyment. This system, called the endocannabinoid system (or ECS), is a group of specialized signaling chemicals (think “keys”), their receptors (think “locks”), and the metabolic enzymes that produce and break them down. These endocannabinoid chemical signals act on some of the same brain and immune cell receptors (CB1 and CB2) that plant cannabinoids like cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) act on

How Does THC Produce Its Effects and Get Us High

Simply put, THC works by binding to cannabinoid receptors concentrated in the brain and central nervous system to produce intoxicating effects. But does that mean our bodies evolved for cannabis?

Well, not quite. Before envisioning a symbiotic relationship between cannabis and humans, it’s important to be introduced to “endogenous cannabinoids” such as anandamide and 2AG – the human body’s naturally occurring cannabinoids. You may be familiar with anandamide if you’re, say, a runner and have experienced the wave of euphoria after a successful jog, commonly known as “Runners high”

The bottom line? Our bodies evolved to interact with natural cannabinoids such as anandamide, but this same system is responsible for the effects experienced from THC and other cannabinoids.

What to Expect from a THC High

THC has a wide range of short-term effects which may or may not be experienced depending on the individual. For example, while some may find that THC elicits strong feelings of calm and peace, others may notice an increase in their anxiety levels. The difference can be as simple as one’s own body chemistry, but certain strains and varying concentrations of THC can also create different outcomes in how one feels

Some short-term effects of THC include:

  • Elation

  • Relaxation

  • Sedation

  • Pain relief

  • Memory impairment

  • Energy

  • Hunger

  • Drowsiness

  • Increased heart rate

  • Dry mouth

  • Slowed perception of time

  • Laughter

  • Dizziness

  • “Couch-lock,” or feeling heavy

  • Anxiety/paranoia

There is very little concrete evidence to support theories about the long-term effects of THC. Research is ongoing and inconclusive, and with time, some of the prevailing theories may be confirmed or ruled out entirely. That said, research into the long-term effects of THC currently includes the following potential effects.

Anatomical Brain Changes: In a recent study researchers found a link between frequent high-THC consumption and anatomical alterations in a region of the brain called the corpus callosum, which connects the two cerebral hemispheres. Using data from participants who self-reported their cannabis use, researchers found that daily consumers of high-potency THC strains showed differences in corpus callosum microstructure compared to occasional consumers and those who had never consumed cannabis. However, the anatomical differences between frequent consumers of high-THC cannabis and the other groups could not be linked with psychosis, which was another key variable that researchers in this study considered. In addition, it’s important to note that due to the self-reported nature of this study, there is no independent verification of the accuracy of these results.

Psychosis: Only truly a concern for those predisposed to certain psychotic conditions such as schizophrenia and other such disorders,research has found the onset of symptoms may develop an average of three years earlier with regular cannabis use.

Tolerance: The body naturally builds up a tolerance for THC with extended, long-term use. The downside to this is that increased levels of consumption will be required to achieve the desired effects. A simple solution? Tolerance Breaks

Hope you found this post helpful . Until next time